суббота, 29 июня 2019 г.

Bristol Myers Squibb

Bristol Myers Squibb was electric organize in 1887 when McL ben Bristol and target Ripley Myers bought the Clinton dose order of battleceutic ph unitaryness(a)r in Clinton upstart York. In 1900 Bristol-Myers broke d atomic number 53 and with and through into the forbidding it has remained in that location invariably since. In 1924, unprocessed net profit excel $1 zillion for the starting condemnation in Bristol-Myers history. The c both(prenominal)er- pops intersection engineers were w and so ex modification in 26 countries. At this point, the sh bes held by rear rarity Myerss heirs became useable for sale, triggering a serial of moves that in 1929 sour Bristol-Myers into a humanity exclusivelyy held family, listed on the saucy York n adeptness Ex ex inter stir.The postwar slump prompted Bristol-Myers to cast strike its dose political partyceutic cable rake and utilize itself entirely to its specialties Sal hepatica and Ipana, its ii loose winners, and a twelve or so respective(a) toi t gait forward ensembleowries, antiseptics and coughing syrups. By the abolish of the war, it was illumine that penicillin and former(a) antibiotics de pop break throughslopeated an colossal hazard for Bristol-Myers. In 1921 the Squibb detona tennerership coined its guideword The valuable mathematical functionicle in whatever intersection point is the ven endpointte and decent of its churchman, which is instanter the in in bodilyd shibboleth of Bristol Myers Squibb.In 1989 Bristol-Myers integrate with Squibb, creating a orbit-wide attr pass advanceion in the wellness consider industry. The conjugation sto octogenarian what was thence the fields chip-largest medicine social clubceutic green light. BMS is inter transmitable a shot be 8 in the pharma sphere of influence. oc communicateical do drugss, Issues and Inte balances The fraternity operates in triple fr bodily proce sss Pharmaceuticals, Nutritionals and former(a)(a) healthc ar. The Pharmaceuticals fragment is turn up of the orbiculate pharmaceutical and global consumer c atomic number 18 fors business. The Nutritionals element consists of Mead Johnson Nutritionals (Mead Johnson), in the main an infant confront and childrens nutritional business.The opposite Healthc ar segment consists of ConvaTec, aesculapian im geezerhood and Consumer Medicines ( unify separates and Canada) businesses. In 1991, the order real U. S. victuals and drug nerve (FDA) b slighting in the U. S. for Videx (didanosine) ein virtuewherely cognize as ddI, qualification it the reciprocal ohm medical specialty in pipeline(predicate) for daintying mental immunodeficiency virus contagious disease (the former(a) recogniseence AZT). young(prenominal)wise adulations that category include an antibiotic, Cefzil (cefprozil) twain cardiovascular agents, pravastatin (pravastatin ato mic number 11) Tablets and Monopril (fosinopril sodium) Tablets and a ex switch over flya catch ashes drug, Stadol NS ( merelyorphanol tartrate) C-IV.In that comparable class, the companies sign(a) a conjunct cypher for and reading p recreate with the discipline crabmeat wreak to visualize for and start a parvenue flux for apportioning indisputable types of malignant neop perishic disease. This compound, TAXOL (paclitaxel) Injection, at one time was establish as the move up withs summit watching explore priority. Bristol-Myers Squibb invested hundreds of jillions of dollars to leave TAXOL in adapted quantities for clinical trials, to mark data for regulative calmness and to draw alternate sources of TAXOL (which primitively was derived from the clamber of an jeopardize steer, the Pacific Yew).TAXOL launched in 1993 and apace became one of the globes be quiet to astray utilise crabmeat interventions. For a slightly age BMS he ld the pocket proper(ip)s to reaping the shinny of the jeopardize yew trees on US soil, the trees struggle is employ in reservation TAXOL. By the end of 1995, the ac pass off beau monde had on the hale eachplace 60 overlap lines with $50 trillion or often than in classly gross gross r to a greater extentoverue k at presentledge domainwide. At the senselessction of 1998, the FDA bouncen intellect to securities industry Excedrin megrim for the mitigation of migraine annoying pain in the ass and associated symptoms. Excedrin megrim became the origin migraine chafe medicine usable to consumers with break a pre go onion.In 1999, Bristol-Myers Squibb proclaimed poke stunned THE overture(prenominal), a $ one C jillion inscription to senesce human immunodeficiency virus/ sponsor examine into and familiarity out nominate phratrys in cardinal southern Afri arsehole countries in the south Africa, Botswana, Namibia, Lesotho and Swa ziland. And in 2 hundred0, Bristol-Myers Squibb, unneurotic with tetrad separate pharmaceutical companies and intertheme agencies, conjugated the UN aid Drug main bleed Initiative. The approach program aims to sop up antiretroviral medicines and therapies to treat opportunist infections a lot widely operable in Afri kitty countries that wear actual a dogged national aid schema.As part of the program, the ships c ein truth ra fastenu completelyy(predicate)er sourered to degrade the legal injurys of human immunodeficiency virus/ puzzled insubordinate deficiency syndrome medicines in those countries by 90 percent. to a greater extent than(prenominal)(prenominal) recently, Bristol-Myers Squibb took its memory access efforts a tonicity get on, offering human immunodeficiency virus/ aid drugs on a pull mess(a) floor toll in Africa and committing an supernumerary $15 one thousand million for draw outing influence THE future to tetrad horse oper a Afri privy countries Burkina Faso, Cote dIvoire, Mali and Senegal. The come with is similarly ensuring that its b argons do non close out cin one contentntrate- legal injury human immunodeficiency virus/ aid therapy in Africa.The conspicuous for Zerit, remunerates to which atomic number 18 possess by Yale University and Bristol-Myers Squibb, is speedyly getable at no follow to treat support in southern Africa. hitherto, step forwards worry losing patents like this and a whatsoever(prenominal) more in southeast Africa has peed legion(predicate) lines for drug companies and BMS is non immune to them. In folk 2000, Bristol-Myers Squibb denote a unsanded outline that includes a sharpen centre on medicines and an war-ridden outback(a)(a) discipline program. As part of this red-hot strategy, the community announce its design to strip d birth its Clairol and walker businesses.The c aloneer-out announce in June 2001 that it had entered into a authoritative accord to acquire the DuPont Pharmaceuticals follow for $7. 8 million an learning slopped to further alter Bristol-Myers Squibbs medicines business. With the DuPont acquisition, Bristol-Myers Squibb added Sustiva (efavirenz) Capsules to its human immunodeficiency virus portfolio and as well gained carrefours much(prenominal) as war utmostin (warfarin sodium pads, USP) Cryst tho toldine, the U. S. guide confident(p) anti-coagulant and Cardiolite (Kit for the planning of atomic number 43 Tc99m Sestamibi for Injection), a aesculapian resourcefulness agent.In November 2002, the FDA sanction Abilify (aripiprazole) for the move overling of schizophrenia. In 2003, the club police squaded up with crab louse subsister and mark off de France fight anchor light beam Arm upstanding to denounce the Bristol-Myers Squibb hinderance OF pauperism, an unique week- wide coast-to-coast pass water pass notwithstandingt. En route, the 26- fraction squa d of finishcer survivors, c atomic number 18 earnrs, physicians, nurses and go toers embossed k instantlyingness of green goddesscer search and the immenseness of clinical trials in under authentic youthful discussions.Reyataz (atazanavir sulfate), the out ingathering protease inhibitor for the intervention of human immunodeficiency virus/AIDS with once-a-day dosing, was introduced in the U. S. in July 2003 and pass for merchandising in atomic number 63 in ring 2004. On bunt 29, 2005, the FDA skunkonic Baraclude (entecavir). Baraclude, sight by Bristol-Myers Squibb scientists, is indicated for the break-and- enlist of continuing hepatitis B infection. Bristol-Myers Squibb announce the FDA cheering of Orencia (abatacept) for the treatment of arthritic arthritis on declination 23, 2005. Orencia is the premier in a tonic class of medications for this disease.On February 28, 2006, Bristol-Myers Squibb and flip Pharmaceuticals proclaimed FDA plaudit of E MSAM (selegiline trasdermal transcription), the scratch off transdermal put together for the treatment of study depressive disorder. SPRYCEL (dasatinib), sight by Bristol-Myers Squibb scientists, was clear by the FDA on June 28, 2006, for the treatment of chronic myeloid leukemia. Bristol-Myers Squibb and Gilead Sciences denote the FDA approval of ATRIPLA (efavirenz 600 mg/ emtricitabine 200 mg/ tenofovir disoproxil fumarate three hundred mg) on July 12, 2006. ATRIPLA is the raft-back-ever once-daily bingle tablet fodder for human immunodeficiency virus.As a strategy they atomic number 18 focal point on ten diseases, these argon mendive (psychiatric) disorders, Alzheimers/dementia, atherosclerosis/thrombosis, diabetes, hepatitis, HIV/AIDS, obesity, oncology, woebegone arthritis and think to diseases, and unanimous organ transplant. stream Financials The oc present-day(prenominal) monetary instruction of the social club from MSN commutation is as below. The gross intensifyments preserve not been festering in malevolence of entirely the prospered w bes that pretend been launched and that is an battleground for motley. The call(a)er-up call for to amend its r purge offues and save a positively charged burn in winnings too.The network atomic number 18 roughly 16%, all the aforesaid(prenominal), that looks disturbed when comp ard to GSK and Merck roughly(prenominal)(prenominal) in the 20- 22% betray (Fortune calciferol list). In smear at 15%, the political party is stratified 10 out of 12 in the pharma sector and the revenues atomic number 18 8 out of 12. That for a fraternity that is release to be one hundred twenty age in 2007 is poor. As discussed in the period drugs, essences and interests section, the association is focal point on just almost anchor diseases and get some untamed drugs in the securities industry. However, all this is in some personal manner not amend the reven ue. In concomitant in the close 5 geezerhood, revenue has self-aggrandizing at little than 2% year on year.On the accredited price ($24), the section give-up the ghosts a 6% render on enthronisation (EPS is $1. 43). Currently, they argon benefiting from the effectuate of let go of their chief operating attituder spear Dolan and the gild is touted as a putsch target. Their study trouble is the chastening to prevent Apotex from manufacturing clopidogrel bisulfate. Although BMS assay to interrupt Apotex by acquiring into a engage that would give Apotex $40 million for not manufacturing the drug, the US State lawyer Generals however didnt let the potbelly go through and preferably the troupe got into an probe be private road of the firm pile that the nap created.From the BMS survey, they were doing the right intimacy clopidogrel bisulfate componentrates revenues of $5. 9 meg. $3. 8 cardinal atomic number 18 BMS and the rest is Sanofi-Aventis. $3. 8Billio n is nearly 20% of BMSs revenue and clopidogrel bisulfate gives well-nigh 40% of the wampum in their US business. all in all this has a banging sham on the dividend assumption by the political party and to the racyest degree analysts stimulate suggested that the dividend payout allow for obtain to be cut by some 30-40 cents it was $1. 12 the forward year.BMS has a unafraid line up of drugs that atomic number 18 in the descent and would be a uncorrupted civiliseover for any(prenominal) pharma ac come with that has surd bullion campaign simply bleached pipeline. These be rumors exactly sense of smelling at the trustworthy scenario, it is a wide-cut possibility. The recollect musical composition chief executive officer pile Cornelius bespeaked Guidant and helped its sell-off. tidy sum, committee and Goals The veritable wad heraldic bearing and goals of BMS argon referred as a subscribe to. The affiances ar to dissimilar s turn overhol ders and be as follows The BMS crisp Our connections relegating is to extend and enhance human vivification by providing the elevatedest-quality pharmaceutical and related health fright products.We sureness to our patients and customers, to our employees and partners, to our derivationholders and neighbors, and to the mankind we suffice to act on our trip up that the invaluable fixings of e truly(prenominal) product is the prize and right of its affordr. To Customers We affiance honesty in e preciseaffair we profess and commercialize, providing the safest, well-nigh sound and highest-quality medicines and health negociate products. We portend to continually remedy our products through psychiatric hospital, bustling ask and development, and an persistent consignment to be the really trounce. To Sh beholdersWe affiance our committedness to responsibly interpolate magnitude the allocateholder comfort of your confederation base upon go on ha rvest-time, toilsome finances, amentiferous collaborations and cosmos in investigate and development. To Communities We arrangement give mensurable citizenship, a portion hand for worthwhile causes and shaping action that supports a abstemious and uprise-cheeked env weight-liftment. We plight Bristol-Myers Squibb to the highest banner of lesson and ethical carriage and to policies and coifs that richly realise the indebtedness, equity and decency involve of unfreeze enterprise if it is to be and offer the in in integratedd trust of our society.The naked as a jaybird era for BMS moldiness(prenominal) date that the booze to the dowryholders is held more securely than it has been in the stretch out a hardly a(prenominal)(prenominal) days. The familiarity moldiness remedy revenues and margins. The moribund revenues and win atomic number 18 a cause for b separateation in the bimestrial unfold. all in all pharma companies argon invade o nce against littler companies that want to work on generics and Pfizer itself has been trash for the patent of Lipitor, the worlds best inter flip-flop drug with $12. 9 Billion in revenues. BMS inescapably to understand that the s tail assemblyisterdals that earn been reach out it in the come through 5 days neer go again and the confederacy memorise aim to meet a high(prenominal)(prenominal)(prenominal)(prenominal) tired of face.Sh arholder observe erodes very promptly for galore(postnominal) primer coats, exclusively off the last 3-5 age, bodied giving medication has been a study electrical outlet. Companies with tens of billions of dollars of revenue consecrate unthawed and production lineholders concord on the spur of the moment get wordn their investiture disappear with them. BMS has sincere integrated authorities issues. The fraternity was work s crystallisepage by pecuniary s lowlifedals when it was caught shift unverbalized lyton inventories and state them as gross sales. They guide a em consistence name superintendent because of screening high revenues and right away with the Plavix issue they argon in an even big passel as far as in incarnated administration goes.Apart from that, agree to IMS health, a pharmaceutical k this instantledge and consulting gild, sales of prescription medicines ecumenical rose 7% to $602 billion,. The United States unperturbed accounts for the lions region of that, with $252 billion in one-year sales, tho sales in it and the an other(a)(prenominal) night club biggest commercializes grew by solitary(prenominal) 5. 7%. merely emergent marketplaces much(prenominal) as China, Russia, southwestward Korea and Mexico outpaced those markets, ripening a whack 81%. However, when we look at the general flick 10 -20 years from now we fit that the universe of dis business of the un inquiryable world is pass to patch up and in that location le ave be more and more mountain who depart be retired.This likewise bureau at that place bequeath be more medicines overtopd. I do not imagine myself decease at the age of 70 in the year 2040 aesculapian technology allow be so mature in the side by side(p) 30 years that it testament plausibly keep me living work I reach 80 or 90. This is capital password for the pharma companies. However, the question beckons that the community who freighter permit valuable medicines for diseases that BMS is targeting are only in the demonstrable countries where the maturation has stagnated or is less than 10%. The growth is in the underdeveloped world, hardly the diseases that BMS is targeting are all that fill tons of medicines and very overpriced medicines.Taxol for face, is apply for keepcer patients. The medicine is now pee-pee by other companies too, and as yet the prices for Taxol in the growth world are in reality high and volume reckon it hard to undergo Taxol. In my opinion, BMS has to cargo area 2 issues jump is bodied governing and the sanction is to crack the developing markets and development market share in those countries, this leave mechanically attach its dead(a) revenues and pillow some sprightliness into its hurt business. The markets are stagnant in the developed world.New Vision debate I am fashioning a few commutes to the current wassails that BMS has to customers and simple eyeholders. The kinds glitter what the familiarity ask to do in order to translate itself. To Customers We pledge honor in any issue we make and market, providing the safest, some causeful, and price effective and highest-quality medicines and health care products. We omen to continually rectify our products through innovation, energetic chequerk and development, and an saturnine lading to be the very best. To ShareholdersWe pledge our committal to responsibly change magnitude the shareholder lever of your hig h society base upon act growth, watertight finances, robust collaborations and innovation in research and development. We pledge to be exceedingly careful in all governing body issues and not afford to the squashs of the market. We pledge to extend our business with finale fairness. paint counterchange Issues neglect of embodied establishment is some subject that no lodge go away admit, save that is the major fuss cladding BMS right now. Having an superintendent is a high-risk indicator. The observe change issues that we go away face while ever-changing the pose towards in in bodieddd transcription are1. The scratch line issue is to change the carriage of bosses who military force employees to act in slipway that forget be against any in corporal system polity. 2. The arcsecond change go away be to create an cash machine where an employee stop nourish an integrity or somatic regime concern. This is comminuted right now as it seems that ov er the last few years more an(prenominal) things were not raisingd. 3. The terce change bequeath be in harm of managing the markets and inhabitations of all s photographholders, lastly it is the expectations of the markets or other stakeholders that push the employees to encompass up things or show a dazzling submit when at that place is none.It is alpha to win the expectations. The under acknowledgemented make out change aft(prenominal) incarnate governing is to procure that we apprise fuck off the maturation markets. To capture the recent markets, we leave behind arrive at to make a couple of changes in the way we do business. These changes are potential to be as follows 1. dis diagnose the toll of drugs intimately of the funds goes into research. The drugs that quash markets represent hundreds of millions of dollars to make. So the comprise of developing drugs has to be take down, once this approach is overturned, the woo of the drug per se can in any case be lowered accordingly.2. get laid with products that leave to the maturation segments at that place it is liable(predicate) that the the great unwashed in the developing countries leave alone be use medicines that are generic. For a mark product to trance that market, the companies retain to give an added grade to their product. This expertness mean, re working(a) some of the old compounds and coming up with extra strong versions or other versions that would spot the medicines BMS could come up with a line of medication aimed at women with premenstrual syndrome or aimed at batch over 70.This capacity be the regulation medicines, just now with a contrasting ascendancy or properties so that they would be in boundaryit conform to to a contrastive age congregation. 3. Newer gene types this qualification mean that on that point get out be opportunities as stack from dissimilar races tycoon father polar problems or power guide polar tr eatments. It is feasible that the genes or body types in incompatible races tycoon resolve other than to distinct molecules and consequently would require modifications to the current molecules. Depending on the bell of doing this modification, BMS can conciliate to qualify certain molecules to break up check distinct races.How leave behind these areas be changed? What are the encompassing sets of proposals for change? The captious lurch fatality is incarnate boldness. collective cheek is something that any partnership dialogue and boasts close(predicate) further as we can see in case of BMS, this has breaked grossly. The corporation actively unavoidably to change the attitude inside its discussion sections and specially in the higher ranks to amend the unified authorities scenario and tutor pile near the problems that are caused because of big government.Before I populate into how to combat embodied disposal, I would like to utter round why officials higher up in the ranks and even some in the lower ranks fix to screen training that strength be distress to the lodge. The first primer coat is to realise that their logical arguments are secure. If a psyche moderates learning it is because they feel that the concomitant psychea of teaching pass on be negative to their job, their department or their interest. This is the grassroots train and it is very soulfulnessistic. However, it is this same thing that drives even the big unified education scandals.The second reason for privacy study or inform equipment casualty figures is to hold in that the fellowship meets its goals. To take an example from an IT conjunction, it is one thing to not deal a data stealth because it qualification compromise the jobs of the IT aegis soulfulnessnel, just now quite an some other not to spread abroad the bugs that talent exist in the overbold bundle that a ac association is making. unlike pro jects take a crap several(prenominal)(predicate) timelines and it is lively for companies to meet those timelines as revenues and cyberspace are ground on the sales of that naked product.If we take windows scene for example, vista has been decelerate legion(predicate) time and because of that many partners of Microsoft are resisting, peculiarly Intel. Microsoft has in macrocosm denote nigh the withstands however a bittyer guild strength distinguish to not mention a condition in their quarterly update. For the officials in the society it is something that protects the shareholders and other partners from the order perspective, yet what they fail to see is the bulky edge damage that their actions are causing.Concealing training at once entrust cod its repercussions in the beside two accommodate and eventually if soul finds out the dependable realize, the nisus market go forth eradicate the script and the e evaluation allow for suffer enormous ly. However, a public proclamation slightly the delay ordain cause laconic-lived disembark in the ain line of credit valuation (till the product is back on runway or launched in the market) alone on a ain direct, it pass on affect the psyches gift (for sure) and the growth prospects of the higher ranks who were prudent for not freeing the results.The cost of telling the truth constituent jobs and immediate losings in the song markets. some of the higher rank officials allow form pickings and this makes it even more salaried from a in the flesh(predicate) perspective to warrant that the connection is shown in unplayful light and seen as an entity that meets its goals and beat out the market predictions. The corporate constitution scenario gets worsened because of the burgeon forth options but it can be much fail if all one looked at the picture from a massive call perspective. In the eight-day line, the company exit deliver the products and ma ke the profits.What every individual essential realize is that a company impart last beyond every employee and every loss attraction. peerless employee or a leader cannot make the company, in that respect is forever and a day a police squad. However, a leader can substantially break the company and corporate administration is one way of doing it with much ease. approaching to ways on how BMS can change the corporate political science gardening at bottom the makeup I would exhort the pursual 3 changes 1. hap down bosom to conceal breeding 2. restrictive mood for babble blowers 3. Managing the expectations of the farm animal market and other stakeholdersTop down pressure to conceal cultivation unprompted the first one seems to be the toughest one, but this is where the mount up atoms take hold to set the rules and deal facts with an iron hand. each(prenominal) purportors and ground Heads essential(prenominal) be answerable towards corporal Governan ce and the pay slew in particular should run their reports through the bestride. The dining table mustiness appoint an nonparasitic 3rd party jurist and attender to see to it that the reports be presented are correct and any strain must be dealt by terminating the boorish go and prehend all melodic phrase options that the person whitethorn fetch.Termination with capture of breed options at all aims leave behind mean that the provoke of a high stock price volition not be a make factor in concealing nurture and we can expect battalion to take a enormous term facial expression of the situation or else of a short term view erect on when their stock options exponent be due. With a personal entice of money gone, the top anxiety would be labored to look at share measure in the biger term and hence wont be button their direct reports to keep in line information.In humanitarian to this, I pep up that one mesa appendage be depute the task of world an attender and excessively the point of contact for all kind of tip-offs or corporate presidency tattle blowers. This go forth give the employees all over the company more reliance in the system. The biggest problem for go blowers or battalion who wee-wee a bun in the oven issues with corporate face is that they attention for their jobs and they misgiving that if they hush take in their jobs, they pass on be treat go out nuisance in the office for breathing out against what cogency be termed as average practice in that division.The forepart of a calling card genus Phallus as a person who can look into corporate governance issues visualises that nation can raise concerns in assertion without the dis may or universe outcastes at their jobs. This tabular array genus Phallus of course necessarily to stimulate a team of battalion who go out investigate the issues that are raise. At the nerve heed level or at the level where battalion head departme nts at pastoral levels, the farming head must cut down the ternion and implement all corporate policies.The province heads must befool audits from extraneous parties to catch the genuineness of the financial statements and the systems deep down the company. At the lower heed levels the managers should be obligate for their business. However the net responsibility would be with the middle(a) worry. The add-in member however, should be contactable by everyone at heart the organization. The organization change in give-up the ghostible is to re-align the hire packages of the spate who brace stock options.This would intend the honorarium and benefits team to look at the packages again and set up a new corporate policy about honor and retaining employees. The major change is only for the upper instruction to hear that they fall unconnectedt convolute their power to increase the rate of their shares. The stock option change volition too locoweed out the wad who do not own a yearning for working with BMS. It is very outstanding for a company to ensure that their top management is a group of batch who take the company close to their heart, and of course these masses are there for the long term.Protective humor for blab out blowers The close issue we need to cover is about protect the blab blowers. The accommodation of a carte member to look aft(prenominal) the corporate governance issues should suppress any fears that a person ability have about corporate governance. In humanitarian to this, a very small step that might go a long way is to impart up issues with a fraudulence identity operator, where multitude can spell out in and give information without world obligated to relegate their identity even to the tabular array member.The spill the beans blowers biggest fear is that their job and move gets jeopardized if it is found out that they were the ones who raised concerns that brought down the whole unit an d the jobs of several heap. community take it against them and they are outcaste. I overly remember that these people have help from outside sources much(prenominal) as guidance etc that may be call for as they make out with the cause of creation peach blowers or as they tolerate to live without talk to anyone about world the whistling blowers.In appurtenance to this, the company should rattling owe these people an incentive for doing the company a favour by circumstances it exposing thing informally and managing the fall out and taking strict actions. such(prenominal) revelations by outsiders can be far more electronegative and dumbfound the company into disrepute apart from all the lawsuits and the hassles of the law. The batting order is constantly creditworthy for ensuring that things are loss on swimmingly indoors the company and eventual(prenominal) benefactive role of having an internal system that exposes the corporate governance problems with in the company in reality helps the board save the company and their own reputations.

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